Not enough credit is being given to these defenses by how high this total is. San Francisco is the No. 1 defensive team in the NFL ranking first in scoring defense and total defense while placing second in run defense and takeaways. The Eagles easily led the NFL with 70 sacks.

Brock Purdy has been a huge success story surrounded by elite weapons and receiving excellent play-calling from Kyle Shanahan. But Purdy only has started two road games in the NFL and has never faced this level of pass rushers. The Eagles sacked Daniel Jones five times last week. Jones is far more mobile than Purdy.

I'm anticipating the 49ers to go run-heavy, which keeps the clock moving, and Shanahan being extremely careful and conservative with his play-calling. He knows the 49ers will be in trouble if they have to play from behind. San Francisco already plays at the slowest pace of any NFL team.

Jalen Hurts emerged as a superstar this season. But is his passing shoulder 100 percent healthy? Hurts and the Eagles haven't faced a defense this strong all season.

Weather-wise there's a slight chance of a rain shower with the wind blowing at 10-15 mph.